Nocturnal Melatonin Deficiency in Colorectal Cancer: Independent Predictive Value Beyond Sleep Quality.

Hypertension and coronary artery disease were also more frequent in the CRC group, but the differences did not reach statistical significance.

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Second, the relatively small sample size limits statistical power, particularly in the analysis of comorbid conditions and in multivariable models, where some associations may have failed to reach significance due to insufficient numbers.

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