Barely Significant
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Variant allele frequency as a potential marker in response to frontline systemic therapy for patients with locally advanced and metastatic urothelial carcinoma.

Transl Androl Urol · 2026 · PMC13184214 · PMID 42164355

Europe PMCDOI
1
hedged sentence
0.0460
closest p · 0.9× alpha
0.0460
boldest claim

The sentences

nearly significantP=0.046actually significant
The median OS for the patients with median VAF ≥47.2% was 26.0 months (95% CI: 8.8–NR) versus 9.9 months (95% CI: 3.3–23.0) for the patients with median VAF <47.2%, and there was a nearly significant difference in favor of the higher VAF cohort (HR =0.39; 95% CI: 0.15–1.02; P=0.046) ( Figure 4B ).

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