Trends in the Overall Incidence and Mortality of Lung Cancer: An Extensive Longitudinal Study Utilizing the CDC WONDER Database 1999-2020.

Thorac Cancer · 2026 · PMC13184548 · PMID 42152763

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an increasing trendno p-value reported

Males saw steeper declines than females; however, American Indians/Alaska Natives showed an increasing trend (APC 3.96).

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did not reach statistical significanceno p-value reported

While this deceleration in CVS mortality coincides with the FDA approval and clinical integration of ICIs, such as Nivolumab and Pembrolizumab, it did not reach statistical significance as an increase [ 15 , 16 ].

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