Although the differences between groups did not reach statistical significance (P for interaction > 0.05; see Supplementary Figure S7 ), the trend—particularly the diminished correlation in the mutant group—may hold biological relevance.
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ZNF750 suppresses esophageal squamous cell carcinoma by maintaining epithelial barrier-driven mucosal immune homeostasis.
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Furthermore, the average direct effect of ZNF750 on the immune score is highly significant (Supplementary Figure S3 , Supplementary Table S6 ).