Sex differences in behaviors, neuronal activation, and gut-microbiota-metabolic axis in a repeated nitroglycerin-induced chronic migraine model.

J Headache Pain · 2026 · PMC13185197 · PMID 41968333

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.1000

boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

In contrast, although g-Parabacteroides showed sex-specific enrichment, its correlation with behavioral indices did not reach statistical significance ( p > 0.05), potentially due to the high inter-individual dispersion observed in its abundance.

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marginally significantp < 0.10so close (0.05 < p ≤ 0.1)

If the interaction was significant ( p < 0.05) or marginally significant ( p < 0.10), simple effect analyses were performed to compare NTG and VEH within each sex level, as well as to compare sex differences within each treatment level.

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