Increased metallopeptidase activity, compromised endothelial integrity and impaired pathogen recognition revealed by transcriptomics in <i>Angiostrongylus vasorum</i>-infected dogs with hypocoagulability and vascular dysfunction.

No MMP was found among significantly dysregulated proteins, but rather, other peptidases, such as Bone Morphogenic Protein 1 (BMP1), another collagenase, displayed elevated levels in late time points post-inoculation (starting at 75 days post-infection and showing an increasing trend over time).

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While our sample size limits definitive conclusions, we observed a tendency toward prolonged PTT and a near-significant extension of PT in the Inf hypo group.

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