Extracellular matrix remodeling in calcific aortic valve disease: Localized enrichment of type III collagen and LTBP-4.

Although statistical significance could not be obtained due to the inherent heterogeneity of the tissue, an increasing trend in the integrated density of both type I and type III collagen was observed in the fibrotic and calcified regions.

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Although the integrated density of the yellow-orange birefringence did not reach statistical significance, it showed a progressive increase from the pre-lesional to the fibrotic and calcific regions ( Fig. 7C ).

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