Chinese Society of Clinical Oncology breast cancer expert consensus on the diagnosis and treatment of breast cancer brain metastasis (2025).

Transl Breast Cancer Res · 2026 · PMC13187562 · PMID 42170569

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did not reach statistical significanceno p-value reported

( 98 ); in a prospective, single-arm phase II study, individuals with HER2 + metastatic BC and BMs who experienced CNS progression despite prior radiotherapy were administered pertuzumab in combination with high-dose trastuzumab administered at 6 mg/kg per week, resulting in a CNS-ORR of11%, which did not reach statistical significance ( 99 ).

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