Hippocampal transcriptome profiling in a 22q11.2 deletion syndrome mouse model: comparison with human schizophrenia.

Mol Brain · 2026 · PMC13188264 · PMID 41937202

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0911

boldest claim

The sentences

highly significantp < 0.0001actually significant

Spearman’s rank correlation of DE scores revealed a modest but highly significant positive correlation (ρ = 0.199, p < 0.0001), indicating a degree of cross-species correspondence in transcriptional changes (Fig. 5 a, Table S2-3).

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did not reach statistical significancep = 0.0911so close (0.05 < p ≤ 0.1)

Among 23 genes differentially expressed in both species, 21 showed concordant regulation (9 upregulated, 12 downregulated), although the overall overlap did not reach statistical significance (Fisher’s exact test, odds ratio = 1.48, p = 0.0911).

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