Although the VLSQ-8 is a comprehensively validated tool for capturing the behavioral and psychological impact of light aversion, its weak (and in our restricted cohort, marginally significant) correlation with psychophysical thresholds suggests that patients’ self-reports are also potentially heavily influenced by behavioral adaptations (e.g., avoidance of light) or limited by statistical power.
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Topography of Photophobia: Perifoveal Sensitivity Associations in Glaucoma.
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This near-significant trend likely reflects limited statistical power in the restricted glaucoma cohort rather than an absence of association, as supported by the consistent direction and effect size observed in the full-cohort sensitivity analysis ( Supplementary Table S2 , Supplementary Fig.