Consistent with these data, anti-C3a antibody treatment of aged mice significantly lowered IL-1β and monocyte chemoattractant protein 1 (MCP-1), whereas IL-6 showed a trend of reduction and TNF remained unchanged (Fig. 6g−i and Extended Data Fig. 8c ).
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Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
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