The directionality of nominally significant associations is biologically coherent: PTB enrichment of Mycoplasma —a genus established in reproductive tract infection and chorioamnionitis [ 27 , 28 ]—alongside nominal depletion of Prevotella , Sneathia , and Lactobacillaceae , suggests a shift in vaginal community structure associated with PTB.
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Leakage-aware machine learning reveals structured clinical and vaginal microbiome patterns associated with preterm birth in a Mexican cohort.
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