A unified single-cell atlas of HNSCC: Toward characterizing HPV- and sex-associated TME variability.

iScience · 2026 · PMC13191048 · PMID 42181284

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HPV+ tumors showed a trend toward increased B cell abundance, consistent with prior reports of enhanced adaptive immune infiltration in virally driven tumors, whereas HPV- tumors were enriched in innate immune populations, including monocytes, macrophages, and mast cells.

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