Efficiency and immunogenicity of lipid nanoparticle-mediated cardiac mRNA delivery are lipid composition-dependent.

Mol Ther Nucleic Acids · 2026 · PMC13191635 · PMID 42181694

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a clear trendno p-value reported

However, significantly upregulated levels were detected for IFN-γ and IL-18 in the serum of mice treated with C12-200 LNPs, and a clear trend of increased IL-6, IL-1β, TNF-α, and IL-12 p70 levels could be observed ( Figure 5 B).

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