Therapeutic vaccination with a live M. bovis-BoAHV-1 combined vaccine accelerates pathogen clearance and restores mammary homeostasis in dairy cows with natural Mycoplasma bovis subclinical mastitis.

Individual trajectories revealed that while initial inflammation was severe, SCC levels in the SC group showed a highly significant reduction by day 21, and over half of the cows (4/6) achieved negative mastitis status by day 35.

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The milk production of all cows in the SC group and IN group both showed a trend of initially declining and then steadily recovering throughout the observation period.

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