Efficacy and risk analysis of monotherapy and dual immunotherapy in dMMR/MSI-H metastatic colorectal cancer: a meta-analysis based on randomized controlled trials.

BMC Cancer · 2026 · PMC13191953 · PMID 42168914

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did not reach statistical significanceno p-value reported

Finally, while substantial progression-free survival (PFS) benefits were observed in major trials like KEYNOTE-177 and CheckMate 8HW, overall survival (OS) did not reach statistical significance in any individual study.

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