Membrane-initiated estrogen receptor-α signaling in the hypothalamus regulates trabecular bone in femur in female mice.

After sexual maturation, at 16 weeks of age, female POMC-C451A f/f mice showed a trend toward increased body weight, and significant alterations were detected in body composition, including increased total body aBMD, increased lean mass, and reduced fat percentage compared to control mice ( Fig. 1A, B, C, D ).

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