In one study, 1q gain was associated with significant inferior EFS in stages I, III, and IV (the negative impact in stage II did not reach statistical significance). 21 Three (MLPA) studies (n = 212, n = 1,114, n = 128) 18 , 21 , 22 analyzed 1q gain as an independent prognostic factor for OS, including the largest series with >1,000 children.
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