Genotype influences antidepressant discontinuation in a pre-emptive pharmacogenetic testing population.

Pharmacogenomics J · 2026 · PMC13193940 · PMID 42168153

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did not reach statistical significanceno p-value reported

While the CYP2D6 decreased metabolizer group (intermediate plus poor metabolizers) did not reach statistical significance for guideline recommended medications (i.e., paroxetine, venlafaxine, vortioxetine), the individual effect for venlafaxine showed an increased risk of discontinuation (HR = 1.23 [1.01, 1.5], p < 0.05).

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