Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP, and NfL with cognitive impairment in Parkinson's disease.

Front Aging Neurosci · 2026 · PMC13194581 · PMID 42182568

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hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

a strong trendp = 0.08so close (0.05 < p ≤ 0.1)

Cognitive status significantly moderated the association between plasma biomarkers and ERC volume for both p-tau181 (β = −0.39, p = 0.04) and NfL (β = −0.44, p = 0.03), with a strong trend for GFAP (β = −0.46, p = 0.08).

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marginally significantno p-value reported

For p-tau181 and GFAP, the indirect effects in the PD-MCI group were marginally significant, but the moderated mediation indices did not reach significance. 4.

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