Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer's disease in vivo.

Commun Biol · 2026 · PMC13195132 · PMID 41904231

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During resting periods, CA1 pyramidal neurons in APP/PS1 mice showed a trend of shorter ISI during bursting compared to WT controls (Fig. 7D , left; 3.753 ± 0.053 ms for APP/PS1, n = 130 (7 animals); 3.986 ± 0.033 ms for WT, n = 229 (8 animals)).

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