Neoantigen evolution and response to checkpoint inhibitor immunotherapy in colorectal cancer.

Nat Commun · 2026 · PMC13195147 · PMID 41904118

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hedged sentence

0.0240

closest p · 0.5× alpha

0.0240

boldest claim

The sentences

weakly significantp -value = 0.024actually significant

While the maximal neoantigen quality is higher in those DRs without a clonal neoantigen (568.6 ± 718.1) than those with a clonal neoantigen (464.7 ± 609.2), the difference is not large in magnitude and only weakly significant ( t = 2.267, p -value = 0.024) (Supplementary Fig. 3b , right).

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