Cross-species fecal microbiota transplantation alters the carbohydrate metabolic phenotype: insights from Gansu zokor (Eospalax cansus).

In brain tissue, FMT-treated SD rats exhibited a trend toward enhanced glucose metabolism compared with control SD rats under prolonged hypoxia, as evidenced by significantly upregulated PFK protein expression, while PKM1 showed an increasing tendency that did not reach statistical significance.

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These findings suggest that, compared with control SD rats, the hepatic TCA cycle intensity in Gansu zokor exhibits a decreasing trend, and that the concentration profiles of these three enzymes in FMT-treated SD rats follow a comparable trend to that observed in Gansu zokor, also showing a tendency toward reduced TCA cycle intensity.

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