Cinnarizine vs. topiramate for migraine prophylaxis in children: a randomized, double-blind, parallel-group clinical trial.

BMC Neurol · 2026 · PMC13196016 · PMID 42106656

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a numerical trendno p-value reported

In contrast, cinnarizine showed a numerical trend toward a lower incidence of appetite reduction compared with topiramate (4.2% vs. 14.6%).

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did not reach statistical significanceno p-value reported

Appetite reduction was numerically more frequent in the topiramate group, consistent with its known side-effect profile, but the difference did not reach statistical significance in this sample.

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