Reversible synaptic deficits in early-stage batten disease.

J Transl Med · 2026 · PMC13196110 · PMID 42163273

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a slight trendno p-value reported

However, at 3 weeks (presymptomatic), we found no change in inhibitory transmission, with only a slight trend toward reduced frequency at 4 months.

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showed a trendno p-value reported

Total levels of VAMP2 and SNAP25 were unchanged, while VAMP4 showed a trend toward reduction (Supplementary Figure S5 ).

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