Barely Significant
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Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children.

BMC Med · 2026 · PMC13196138 · PMID 41987210

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However, when restricted to the vaccine-only cohort, this association did not reach statistical significance in the 6M–12M period after adjusting for concurrent antibody and S + MBC levels (Fig. 4 A).

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highly significantno p-value reported
This re-estimation confirmed the robust contribution of T cells: the association between T cell responses and reduced infection risk remained highly significant in the total cohort (including hybrid-immune children), with 95% CIs remaining strictly below 1.00 during the late phases (HR 0.39, 95% CI: 0.21–0.62 for 6M–12M).

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