Pulmonary toxicity of brake wear particles: effects of composition and surface reactivity.

In contrast, inflammatory cell–based endpoints showed weaker associations; although the neutrophil percentage correlated moderately with intrinsic ROS generation ( r = 0.55), this relationship did not reach statistical significance ( p = 0.07).

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Although nitrite concentrations showed an increasing trend in the BWP groups, the observed level (approximately 10 μM) was not considered indicative of a major nitrosative contribution to toxicity under the present experimental conditions [ 35 , 36 ].

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