Split-Dose Versus Standard Single-Dose Bowel Preparation Regimens for Colonoscopy: A Systematic Review and Meta-Analysis.

Cureus · 2026 · PMC13196663 · PMID 42181362

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did not reach statistical significanceno p-value reported

Discussion This systematic review and meta-analysis of five RCTs comparing split-dose versus single-dose bowel preparation for colonoscopy found a consistent directional trend favoring split-dose regimens for improving cleansing quality, although the pooled estimate for adequate bowel preparation did not reach statistical significance.

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