Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathways.

We demonstrate a highly significant overlap in dysregulated genes and molecular pathways and between the effects of PCB exposure and Mecp2 mutations.

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While some cell types showed variation across conditions, these differences did not reach statistical significance after correction for multiple comparisons, consistent with previous findings. 23 To further control for any potential effects of cell type proportion variability, we downsampled cells to ensure equal representation across conditions before performing differential expression analysis.

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