Safety and Efficacy of a Novel Atrial Flow Regulator in Patients With Severe Pulmonary Arterial Hypertension: The AFR-Prophet Study.

J Soc Cardiovasc Angiogr Interv · 2026 · PMC13198087 · PMID 42183131

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showed a trendno p-value reported

In particular, the 6-mm group compared to the 8-mm group showed a trend, although not statistically significant, toward a greater increase in both CO (+1.22 [0.13-2.56] L/min vs 0.76 [0.00-1.20] L/min, P = .09) and stroke volume index (8.22 [4.18, 23.60] mL/min/m 2 vs 5.57 [1.52-12.70] mL/min/m 2 , P = .06), in tandem with a greater reduction in PVR (–5.91 [9.32, 2.77] WU vs –2.62 [5.14, 0.93] WU, P = .03).

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