Reduced-Dose vs Full-Dose Direct Oral Anticoagulants for Extended Anticoagulation Therapy in Patients With Venous Thromboembolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

For major bleeding (analyzed using both RR and HR), follow-up duration showed a borderline inverse association (β ≈ –0.03, P = .069), suggesting a potential trend toward greater bleeding reduction with reduced-dose DOAC in longer-duration studies; however, these findings did not reach statistical significance and should be interpreted cautiously.

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