Bitter gourd bioactive peptide alleviates neuronal ferroptosis after spinal cord ischemia-reperfusion injury, combined with emerging cell and animal models.

By contrast, the immunoreactive signal for the anti-apoptotic protein Bcl-2 showed a decreasing trend ( Figure 5A ).

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Notably, although the change in expression of Bcl-2 alone did not reach statistical significance in some groups, calculation of the Bcl-2/Bax ratio ( Figures 2C , 8C ), a more reliable indicator for apoptosis assessment, revealed that this ratio was significantly reduced in both the Model and CoCl 2 groups ( p < 0.05).

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