Multimodal neuroimaging of alcohol use: from acute neurochemical effects to chronic brain network reorganization and precision treatment targets.

Carriers of the A1 allele of the Taq1A polymorphism (linked to the DRD2/ANKK1 locus), associated with reduced D2/3 receptor density, show higher risk for AUD; in an Indian male cohort, the A1 allele showed a trend toward association and a haplotype including A1 conferred an approximately 2.5-fold higher risk ( 146 ).

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