Tear fluid as a novel specimen for detection of alpha-synuclein seeding activity in Parkinson's disease.

NMSS total score showed a weak trend toward a negative association with AUC ( r = − 0.299, p = 0.0292, q = 0.051), but this did not survive correction for multiple comparison.

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In particular, false negative PD patients showed a trend toward higher NMSS scores and significantly greater autonomic and urinary burden than true-positive patients.

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