The impact of APC mutation on the efficacy of anti-EGFR therapy in metastatic colorectal cancer with RAS wild type: a retrospective analysis.

Ther Adv Med Oncol · 2026 · PMC13199703 · PMID 42199488

Europe PMC DOI

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0.2800

closest p · 5.6× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.28not close (p > 0.1)

Similarly, for overall survival, although the APC-mutated group showed a numerically lower hazard ratio, it did not reach statistical significance in this subgroup (HR 0.59, 95% CI 0.23–1.56, p = 0.28; Figure 5 ).

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a favorable trendno p-value reported

Patients with APC mutation showed a favorable trend in PFS as compared to those with APC wild-type (HR 0.72, 95% CI, 0.40–1.30).

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