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Association between circadian rhythm disruption and the risk of malignancy in patients with thyroid nodules: a propensity score-matched study.

Front Endocrinol (Lausanne) · 2026 · PMC13201181 · PMID 42205260

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Notably, the risk magnitude appeared slightly more pronounced in younger patients (<55 years: OR = 3.10, 95% CI: 2.10–4.60) compared to older patients (≥55 years: OR = 2.35, 95% CI: 1.25–4.40), although the interaction term did not reach statistical significance ( P for interaction = 0.182).

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