Induction immunochemotherapy followed by concurrent chemoradiotherapy improves survival in unresectable esophageal cancer: a systematic review, meta-analysis, and network meta-analysis.

Front Immunol · 2026 · PMC13201479 · PMID 42206035

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a favorable trendno p-value reported

CCRT-IO also significantly improved OS in pairwise meta-analyses, but this benefit did not reach statistical significance in the NMA, although a favorable trend was observed.

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did not reach statistical significanceno p-value reported

In contrast, the comparison between CCRT−IO and CCRT alone did not reach statistical significance (HR 0.88, 95% CI 0.78–1.00).

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