Optimization of cultivation strategies for production of recombinant human papillomavirus type 58 major capsid protein L1 in Hansenula polymorpha.

Bioresour Bioprocess · 2026 · PMC13201806 · PMID 42183979

Europe PMC DOI

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a clear trendno p-value reported

Overall, the effects of increasing methanol concentration and supplementation of non-animal-derived nitrogen sources on HPV58 L1 production revealed a clear trend: the volumetric L1 yield increased primarily as a result of enhanced cell growth, whereas the specific yield remained stable or decreased.

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an increasing trendno p-value reported

When glycerol was completely consumed (indicated by an increasing trend of %DO), feed solution (400 g/L of glycerol with 200 g/L of Hy-ExpressTM System II or HySoy) was fed at an exponential rate for Hy-ExpressTM System II.

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