Treatment Outcomes and Prognostic Factors of Metastasis-Directed Radiation Therapy for Oligometastatic Endometrial Cancer.

Although SBRT showed only marginal significance for local control in our cohort, which may be attributable to the relatively modest dose in our cohort, recent studies in oligometastatic disease in gynecologic malignancies highlighted effective local control by SBRT. 11 , 13 , 20 Notably, radiation dose emerged as an independent prognostic factor for OS and PFS in multivariate analyses, despite not being significant in univariate analyses, likely reflecting imbalances in baseline characteristics, as the high-dose group included a higher proportion of patients with nonendometrioid histology.

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In a propensity-matched analysis, repeated MDRT for recurrent oligometastases showed a trend toward improved OS compared with a single course.

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