GPR75 genetic manipulations in mice reveal central mechanism for weight loss independent of developmental effects.

Gene expression analyses showed a trend for increased Ucp1 and Elovl3 in iWAT of sh517-treated mice, but not for Cidea, Prdm16, and Dio2, suggesting partial activation of beiging ( Figure 3 H). iWAT of sh1109-treated mice and BAT of both shRNA groups showed no expression differences for the brown adipocyte and inflammation markers examined ( Figure 3 H–I).

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