Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice.

As observed at 2 h, cytoplasmic JNK activation was modestly increased in HuR Hep−/− male mouse livers but did not reach statistical significance, and overall JNK activation and mitochondrial translocation were comparable between WT and HuR Hep−/− livers at 6 h ( Fig. 7A and B ).

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Interestingly, although Drp1 mRNAs were not significantly altered, Drp1 protein levels showed a decreasing trend following KH-39 treatment ( Fig. 9B ).

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