Single-cell omics uncovers novel pathological mechanisms and therapeutic targets for congenital heart diseases: insights from integrated intercellular communication analysis.

Stem Cell Res Ther · 2026 · PMC13202810 · PMID 41992274

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approaching significanceno p-value reported

Propeller testing [ 71 ] across all CHD conditions versus healthy donor controls identified CM, Tcells, Mast, Mac, and LEC as populations showing statistically significant cell-proportion changes (FDR < 0.05), while EC was approaching significance (FDR = 0.059) (Supplementary Fig. 2B).

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