Effects of HIV and azidothymidine on Alzheimer's-like pathology and amyloid beta transporters in hu-PBL-NSG mice, brain endothelial amyloid beta uptake and endothelial barrier integrity.

Western blot analysis showed that compared to non-infected animals, claudin-5 expression in infected and AZT-treated animals decreased by 1.4 to 1.7-fold although this did not reach statistical significance (Fig. 8 a–c, e), and ZO-1 expression decreased by 1.3 to 2-fold (Fig. 8 a–c, f).

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