DNA methylation profiling in Huntington's disease reveals disease associated changes in the striatum.

Clin Epigenetics · 2026 · PMC13202909 · PMID 42185880

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0350

boldest claim

The sentences

highly significantP = 5.95 × 10 –8actually significant

Two other highly significant regions included a ten probe DMR in RHCG (Šídák -corrected P = 5.95 × 10 –8 ) and a nine probe DMR in COL18A1 (Šídák -corrected P = 9.39 × 10 –8 ).

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nominally significantP = 0.035actually significant

Whilst the HTT region itself did not show nominal enrichment in either the entorhinal cortex or cerebellum, in the entorhinal cortex nominally significant enrichment was observed at GRK4 (chr4:2930232–3052474, P = 0.035).

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