Elucidating the vasoprotective mechanism of Tetrahydrocurcumin: from unbiased transcriptomic discovery to targeted validation of the PI3K/AKT pathway.

BMC Complement Med Ther · 2026 · PMC13203002 · PMID 41963969

Europe PMC DOI

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closest p · 1.0× alpha

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boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

Although these differences did not reach statistical significance ( p > 0.05), likely due to sample size limitations or inter-patient heterogeneity, the pattern of downregulation aligns with our hypothesis that the protective PI3K/AKT signaling axis is progressively compromised as atherosclerosis advances.

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highly significantno p-value reported

The strong enrichment of this particular pathway is highly significant, as it is known to contain crucial upstream regulators, such as PI3K, which directly influence the AKT signaling axis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.