A High-Fidelity Patient-Derived Organoid Platform Recapitulates the Dynamic Metabolic Landscape of Cisplatin Tolerance in Mesothelioma.

Quantitative assessment indicated a trend towards a higher Ki-67 proliferation index in the treatment-naive pairs relative to their cisplatin-tolerant pairs, though this reduction did not reach statistical significance ( p = 0.065) ( Figure 2 e).

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To identify universal drivers of tolerance, the focus of analysis was on the most strictly conserved, highly significant individual transcripts shared across the divergent models.

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