Combined Histidine and Proline Supplementation (HISPRO) Enhances Oxidative and Mitochondrial Function in Skeletal Muscle Through SIRT1-Associated Signaling.

In contrast, OXPHOS complex proteins still showed a non-significant trend toward higher levels in HISPRO-treated cells compared with the control group even under SIRT1 inhibition, although these differences did not reach statistical significance ( Supplementary Figure S4 ), suggesting that HISPRO’s effects on OXPHOS may involve additional mechanism(s) that are at least partly SIRT1-independent. 3.5.

also in 111,027 other papers