Early Initiation of rhGH Therapy Significantly Improves Height Gain and Reduces the Gap to Target Height in Children Born Small for Gestational Age: A Multicenter Retrospective Study.

Children in subgroup A exhibited better H SDS during puberty and showed a trend toward higher AH SDS ( p = 0.059), suggesting that earlier initiation of therapy may be associated with improved AH outcome, in line with previous reports [ 33 , 34 ].

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Finally, there was also a trend towards significance for AH SDS, which was higher in SGA children who started therapy before the age of 7 (−1.59 ± 0.60 SDS vs. −1.93 ± 0.64, p = 0.059).

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