Prognostic Impact of Brain Radiotherapy and Lactate Dehydrogenase in Melanoma with Brain Metastases: A Retrospective Cohort Study.

Cancers (Basel) · 2026 · PMC13204865 · PMID 42192884

Europe PMC DOI

hedged sentences

0.0660

closest p · 1.3× alpha

0.1320

boldest claim

The sentences

a favorable trendp = 0.066so close (0.05 < p ≤ 0.1)

In addition, although the difference was not statistically significant, patients with <3 brain metastases showed a favorable trend toward longer OS compared with those with ≥3 lesions (33.9% vs. 29.7%, p = 0.066).

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did not reach statistical significancep = 0.132not close (p > 0.1)

Systemic treatment was also shown to significantly improve OS in univariate analysis ( p = 0.003), but it did not reach statistical significance in multivariate analysis ( p = 0.132).

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marginally significantno p-value reported

The association was statistically significant in the BRAF + MEK inhibitor (HR = 0.618, 95% CI: 0.429–0.891) and chemotherapeutic regimens (HR = 0.600, 95% CI: 0.405–0.889) subgroups, and marginally significant in the immunotherapy subgroup (HR = 0.672, 95% CI: 0.451–1.002).

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