Beyond Histology: A Dual-Cohort Genomic Analysis of 2901 Endometrial Carcinomas Reveals Class-Level Mismatch Repair Effects and Refines Molecular Classification.

Individual MMR Gene and Combined dMMR Survival Analysis A six-group log-rank analysis comparing MLH1 -mutant ( n = 18; 2 events, 11%), MSH2 -mutant ( n = 27; 1 event, 4%), MSH6 -mutant ( n = 46; 6 events, 13%), PMS2 -mutant ( n = 12; 1 event, 8%), POLE -mutant ( n = 63; 4 events, 6%), and TP53 -mutant ( n = 880; 373 events, 42%) subgroups demonstrated highly significant OS differences (log-rank p = 7.66 × 10 −12 ; Table 2 , Figure 3 ).

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The TP53 -mutant/CNH effect was directionally consistent (HR = 1.11) but did not reach statistical significance in TCGA, likely reflecting the smaller sample size and the predominance of early-stage, treatment-naive tumors in this cohort. 3.7.

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